Two new chemical constituents from Daphne odora Thunb. var. marginata

Nat Prod Res. 2006 Dec;20(14):1290-4. doi: 10.1080/14786410601101860.

Abstract

Two new phenolic constituents, daphnenone (1) and daphneone (2), were isolated from the stem bark of Daphne odora Thunb. var. marginata. Their structures were established on the basis of spectroscopic analysis. Compounds 1 and 2 were tested for cytotoxic activity by MTT assays on five human tumour cell lines, K562, A549, MCF-7, LOVO and HepG2. Compound 1 showed obvious cytotoxic activity against all the five cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry*
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology
  • Daphne / chemistry*
  • Formazans / metabolism
  • Humans
  • Inhibitory Concentration 50
  • K562 Cells
  • Ketones / chemistry*
  • Ketones / isolation & purification
  • Ketones / pharmacology
  • Nuclear Magnetic Resonance, Biomolecular
  • Phenols / chemistry*
  • Phenols / isolation & purification
  • Phenols / pharmacology
  • Plant Bark / chemistry
  • Plant Extracts / chemistry
  • Plant Extracts / isolation & purification
  • Plant Extracts / pharmacology
  • Spectrometry, Mass, Electrospray Ionization
  • Spectrophotometry, Infrared
  • Spectrophotometry, Ultraviolet
  • Tetrazolium Salts / metabolism

Substances

  • Antineoplastic Agents, Phytogenic
  • Formazans
  • Ketones
  • Phenols
  • Plant Extracts
  • Tetrazolium Salts
  • MTT formazan