Burkina Faso belongs to the sicklemic's belt of LEHMAN and is the epicenter of haemoglobin C. This is the reason of this study on the haematological and biochemical parameters of homozygotes SS and double heterozygotes SC in stationary stage. These parameters will be use for comparison during crisis and to evaluate the therapy efficiency. So 20 homozygotes and 20 double heterozygotes were studied. The blood film showed anaemia with an haemoglobin rate average of 7.8 g/dl for SS against 9.8 g/dl for SC (p < 0.001). An serum's iron elevated in 26.3% of the SS with an average of 23 micromoles /l against 36.8% with an average of 21.7 micromoles /l in the SC (p < 0.001). These results show the importance of SS anaemia's and biochemical's disorders in comparison to the SC.