The overall objective of the studies reported here was to evaluate the growth and nutrient utilization responses of pigs to dietary supplementation of phytate- or nonstarch polysaccharide-degrading enzymes. In Exp. 1, growth performance and nutrient digestibility responses of forty-eight 10-kg pigs to dietary supplementation of phytase or a cocktail of xylanase, amylase, and protease (XAP) alone or in combination were evaluated. The growth response of one hundred fifty 23-kg pigs to dietary supplementation of phytase or xylanase individually or in combination was studied in Exp. 2 in a 6-wk growth trial, whereas Exp. 3 investigated the nutrient digestibility and nutrient retention responses of thirty 24-kg pigs to dietary supplementation of the same enzymes used in Exp. 2. In Exp. 1, the pigs were used in a 28-d feeding trial. They were blocked by BW and sex and allocated to 6 dietary treatments. The treatments were a positive control (PC) diet; a negative control (NC) diet marginally deficient in P and DE; NC with phytase added at 500 or 1,000 phytase units (FTU)/kg; NC with xylanase at 2,500 units (U)/kg, amylase at 400 U/kg, and protease at 4,000 U/kg; and NC with a combination of phytase added at 500 FTU/kg and XAP as above. In Exp. 2 and 3, the 5 dietary treatments were positive control (PC), negative control (NC), NC plus 500 FTU of phytase/kg, NC plus 4,000 U of xylanase/kg, and NC plus phytase and xylanase. In Exp. 1, low levels of nonphytate P and DE in the NC diet depressed (P < 0.05) ADG of the pigs by 16%, but phytase linearly increased (P < 0.05) ADG by up to 24% compared with NC. The cocktail of XAP alone had no effect on ADG of pigs, but the combination of XAP and phytase increased (P < 0.05) ADG by 17% compared with the NC treatment. There was a linear increase (P < 0.01) in Ca and P digestibility in response to phytase. In Exp. 2, ADG was 7% greater in PC than NC (P < 0.05); there were no effects of enzyme addition on any response. In Exp. 3, addition of phytase alone or in combination with xylanase improved (P < 0.05) P digestibility. Phosphorus excretion was greatest (P < 0.01) in the PC and lowest (P < 0.05) in the diet with the combination of phytase and xylanase. The combination of phytase and xylanase improved P retention (P < 0.01) above the NC diet to a level similar to the PC diet. In conclusion, a combination of phytase and carbohydrases improved ADG in 10-kg but not 23-kg pigs, but was efficient in improving P digestibility in pigs of all ages.