Effect of beta-endorphin on production of antibodies and IL-4 under conditions of opioid receptor blockade

S V Gein; T A Baeva; O A Kichanova

doi:10.1007/s10517-006-0334-6

Effect of beta-endorphin on production of antibodies and IL-4 under conditions of opioid receptor blockade

Bull Exp Biol Med. 2006 Aug;142(2):226-9. doi: 10.1007/s10517-006-0334-6.

[Article in English, Russian]

Authors

S V Gein¹, T A Baeva, O A Kichanova

Affiliation

¹ Analytic Laboratory of Institute of Ecology and Genetics of Microorganisms, Ural Division of Russian Academy of Sciences, Perm'. gein@iegm.ru.

PMID: 17369946
DOI: 10.1007/s10517-006-0334-6

Abstract

beta-Endorphin in vivo produced different effects on antibody production depending on the administered dose. Blockade of opioid receptors with naloxone (but not naltrindole) abolished the effects of beta-endorphin. The peptide activated IL-4 production in vitro via activation of delta-opioid receptors.

Publication types

Comparative Study

MeSH terms

Animals
Antibody Formation / drug effects*
Dose-Response Relationship, Drug
Hypersensitivity, Delayed / etiology
Interleukin-4 / metabolism
Lymphocyte Activation / drug effects
Male
Mice
Naloxone / pharmacology
Naltrexone / analogs & derivatives
Naltrexone / pharmacology
Narcotic Antagonists*
Phytohemagglutinins
beta-Endorphin / pharmacology*

Substances

Narcotic Antagonists
Phytohemagglutinins
Interleukin-4
Naloxone
Naltrexone
beta-Endorphin
naltrindole