Small RNAs controlling outer membrane porins

Poul Valentin-Hansen; Jesper Johansen; Anders A Rasmussen

doi:10.1016/j.mib.2007.03.001

Small RNAs controlling outer membrane porins

Curr Opin Microbiol. 2007 Apr;10(2):152-5. doi: 10.1016/j.mib.2007.03.001. Epub 2007 Mar 21.

Authors

Poul Valentin-Hansen¹, Jesper Johansen, Anders A Rasmussen

Affiliation

¹ Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark. valentin@bmb.sdu.dk

PMID: 17369078
DOI: 10.1016/j.mib.2007.03.001

Abstract

Gene regulation by small non-coding RNAs has been recognized as an important post-transcriptional regulatory mechanism for several years. In Gram-negative bacteria such as Escherichia coli and Salmonella, these RNAs control stress response and translation of outer membrane proteins and therefore are key regulators of environmental stress. Recent work has revealed an intimate interplay between small RNA regulation of outer membrane proteins and the stress-induced sigmaE-signalling system, which has an essential role in the maintenance of the integrity of the outer membrane.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bacterial Proteins / genetics*
Gene Expression Regulation, Bacterial
Gram-Negative Bacteria / metabolism*
Porins / genetics*
RNA, Bacterial / metabolism*
RNA, Untranslated / metabolism*
Sigma Factor / metabolism
Transcription Factors / metabolism

Substances

Bacterial Proteins
Porins
RNA, Bacterial
RNA, Untranslated
Sigma Factor
Transcription Factors
sporulation-specific sigma factors