Antiatherogenic effect of grape flavonoids in an ex vivo model

N A Nikitina; I A Sobenin; V A Myasoedova; V V Korennaya; A A Mel'nichenko; E M Khalilov; A N Orekhov

doi:10.1007/s10517-006-0260-7

Antiatherogenic effect of grape flavonoids in an ex vivo model

Bull Exp Biol Med. 2006 Jun;141(6):712-5. doi: 10.1007/s10517-006-0260-7.

[Article in English, Russian]

Authors

N A Nikitina¹, I A Sobenin, V A Myasoedova, V V Korennaya, A A Mel'nichenko, E M Khalilov, A N Orekhov

Affiliation

¹ Institute of Physicochemical Medicine, Ministry of Health of the Russian Federation; Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences. nikitina@zmail.ru

PMID: 17364057
DOI: 10.1007/s10517-006-0260-7

Abstract

The effects of grape phytoestrogens on cholesterol accumulation were studied in primary culture of human blood monocytes incubated with blood serum from postmenopausal women obtained before and 2, 4, and 6 h after single intake of plant components of grapes. Phytoestrogens from grape seeds, pressed out grapes, and fermented grape ridges prevent cholesterol accumulation in cells and can be regarded as prospective components for the development of natural preparations for the prevention of atherosclerosis in postmenopausal women.

Publication types

Comparative Study

MeSH terms

Atherosclerosis / blood*
Atherosclerosis / prevention & control
Cholesterol / metabolism*
Female
Flavonoids / blood
Flavonoids / pharmacology*
Humans
Middle Aged
Monocytes / drug effects*
Monocytes / metabolism
Phytoestrogens / blood
Phytoestrogens / pharmacology*
Postmenopause / blood*
Time Factors
Vitis / chemistry*

Substances

Flavonoids
Phytoestrogens
Cholesterol