N-WASP generates a buzz at membranes on the move

Tatyana Svitkina

doi:10.1016/j.cell.2007.02.028

N-WASP generates a buzz at membranes on the move

Cell. 2007 Mar 9;128(5):828-30. doi: 10.1016/j.cell.2007.02.028.

Author

Tatyana Svitkina¹

Affiliation

¹ Department of Biology, University of Pennsylvania, 415 S. University Avenue, Philadelphia, PA 19104, USA.

PMID: 17350569
DOI: 10.1016/j.cell.2007.02.028

Abstract

The fast-growing ends of actin filaments push against membranes to create cell-surface protrusions and to propel the movement of membrane vesicles. Co et al. (2007) now show that the neural Wiskott-Aldrich syndrome protein (N-WASP) mediates dynamic attachment between membranes and the growing ends of actin filaments to sustain membrane movement.

Publication types

Comment

MeSH terms

Actin Cytoskeleton / metabolism
Actins / metabolism*
Animals
Cell Membrane / metabolism*
Microfilament Proteins / metabolism
Protein Structure, Tertiary
Rats
Wiskott-Aldrich Syndrome Protein, Neuronal / metabolism*

Substances

Actins
Microfilament Proteins
Wiskott-Aldrich Syndrome Protein, Neuronal