Effect of a commercial extract of Paullinia cupana (guarana) on the binding of 99mTc-DMSA on blood constituents: An in vivo study

R S Freitas; S R F Moreno; G L Lima-Filho; A S Fonseca; M Bernardo-Filho

doi:10.1016/j.apradiso.2007.01.015

Effect of a commercial extract of Paullinia cupana (guarana) on the binding of 99mTc-DMSA on blood constituents: An in vivo study

Appl Radiat Isot. 2007 May;65(5):528-33. doi: 10.1016/j.apradiso.2007.01.015. Epub 2007 Feb 6.

Authors

R S Freitas¹, S R F Moreno, G L Lima-Filho, A S Fonseca, M Bernardo-Filho

Affiliation

¹ Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcantara Gomes, Universidade do Estado do Rio de Janeiro, Avenida 28 de Setembro, 87 Fundos, 4 Andar, Rio de Janeiro 20551-030, Brazil.

PMID: 17350271
DOI: 10.1016/j.apradiso.2007.01.015

Abstract

We studied the influence of a commercial extract of Paullinia cupana (guarana) on the binding of technetium-99m-dimercaptosuccinic acid ((99m)Tc-DMSA) on blood constituents. Plasma (P) and blood cells (BC) from Wistar rats (control and treated) were separated. P and BC were precipitated with trichloroacetic acid (TCA) or ammonium sulphate (AS) and soluble (SF) and insoluble fractions (IF) isolated. The percentage of incorporated radioactivity (%ATI) in each fraction was determined. The treatment influenced the %ATI in IF-P and in IF-BC isolated by TCA precipitation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Cells / drug effects
Blood Cells / metabolism*
Female
In Vitro Techniques
Paullinia / chemistry*
Plant Extracts / pharmacology*
Plasma / drug effects
Plasma / metabolism*
Rats
Rats, Wistar
Technetium Tc 99m Dimercaptosuccinic Acid / metabolism*

Substances

Plant Extracts
Technetium Tc 99m Dimercaptosuccinic Acid