Abstract
The effects of ostreolysin, a cardiotoxic cytolysin produced by the edible oyster mushroom (Pleurotus ostreatus), were studied on tension development in isolated rat aortic ring. Its cytotoxic effects on human umbilical vein endothelial cells and Chinese hamster lung fibroblasts were also studied. Ostreolysin induced a concentration-dependent increase in aortic ring tension in the range from 5 to 30 microg/ml, and was cytotoxic to both cell lines. These effects could contribute significantly to its previously observed cardiotoxicity.
Publication types
-
Comparative Study
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Aorta / drug effects*
-
Aorta / physiology
-
Cell Line
-
Cell Survival / drug effects*
-
Cricetinae
-
Cricetulus
-
Endothelial Cells / drug effects*
-
Fungal Proteins / analysis
-
Fungal Proteins / toxicity
-
Hemolysin Proteins / analysis
-
Hemolysin Proteins / toxicity*
-
Humans
-
Muscle Tonus / drug effects*
-
Pleurotus / chemistry*
-
Rats
-
Tetrazolium Salts
-
Thiazoles
Substances
-
Fungal Proteins
-
Hemolysin Proteins
-
Tetrazolium Salts
-
Thiazoles
-
ostreolysin
-
thiazolyl blue