Pig-to-non-human primate heart transplantation: immunologic progress over 20 years

Xiaocheng Zhu; Frank J M F Dor; David K C Cooper

doi:10.1016/j.healun.2006.12.005

Pig-to-non-human primate heart transplantation: immunologic progress over 20 years

J Heart Lung Transplant. 2007 Mar;26(3):210-8. doi: 10.1016/j.healun.2006.12.005.

Authors

Xiaocheng Zhu¹, Frank J M F Dor, David K C Cooper

Affiliation

¹ Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.

PMID: 17346622
DOI: 10.1016/j.healun.2006.12.005

Abstract

The major developments in pig-to-non-human primate heart xenotransplantation during the past 20 years are summarized, largely through the experience of one investigator. Genetic modifications to organ-source pigs have been important steps in increasing heart xenograft survival from a few minutes in 1986 to 2 to 6 months in 2005.

Publication types

Historical Article
Review

MeSH terms

Animals
Heart Transplantation / history
Heart Transplantation / immunology*
Heart Transplantation / trends
History, 20th Century
History, 21st Century
Primates*
Swine*
Transplantation Immunology*
Transplantation, Heterologous / history
Transplantation, Heterologous / immunology*
Transplantation, Heterologous / trends