Abstract
How the mechanisms of dosage compensation distinguish the sex chromosomes from the autosomes has been something of a mystery. A recent study in Caenorhabditis elegans has identified clusters of two common DNA motifs as a cis-acting code for the recruitment of the DCC, the protein complex that mediates dosage compensation.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Binding Sites / genetics
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Caenorhabditis elegans / genetics*
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DNA / genetics
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DNA / metabolism*
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Dosage Compensation, Genetic / genetics
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Dosage Compensation, Genetic / physiology*
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Multiprotein Complexes / genetics
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Multiprotein Complexes / metabolism*
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Protein Binding*
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Species Specificity
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X Chromosome / genetics*
Substances
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Multiprotein Complexes
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DNA