Abstract
The growth factors erythropoietin and granulocyte-colony stimulating factor have hematopoietic and non-hematopoietic functions. Both are used clinically in their recombinant forms. Both also have interesting tissue-protective effects in other organs, which are unrelated to their hematopoietic functions. They have clinical hematopoietic uses in neonatal populations and in experimental non-hematopoietic research, and clinical potential as neuroprotective or tissue-protective agents.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Central Nervous System / drug effects*
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Clinical Trials as Topic
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Erythroid Precursor Cells / drug effects
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Erythropoietin / pharmacology*
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Granulocyte Colony-Stimulating Factor / pharmacology*
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Granulocyte Precursor Cells / drug effects
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Humans
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Neuroprotective Agents / pharmacology*
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Recombinant Proteins
Substances
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Neuroprotective Agents
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Recombinant Proteins
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Erythropoietin
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Granulocyte Colony-Stimulating Factor