Population genetic data on four STR loci, PAI (CA)n, GpIIIa (CT)n, PLAT (TG)14 (CA)12, and NOS2A (CCTTT)n, in Mediterranean populations

Leg Med (Tokyo). 2007 Jul;9(4):218-20. doi: 10.1016/j.legalmed.2007.01.001. Epub 2007 Feb 22.

Abstract

In the present study, we have analyzed four highly polymorphic regions (STRs) chosen from four candidate genes involved in: (1) Platelet aggregation: alpha subunit of the platelet GpIIb/GpIIIa integrin complex (GpIIIa (CT)n; 17q21.31), (2) Coagulation fibrinolysis: Plasminogen Activator Tissue (PLAT5 (TG)14(TA)12; 8p12-q11.2) and Plasminogen Activator Inhibitor-1 (PAI-1 (CA)n; 7q21.3-q22), (3) Oxidative metabolism: the inducible nitric oxide (NO) synthase (iNOS) gene (NOS2A (CCTTT)n; 17cen-q11.2). Allele frequencies for these four STR loci were investigated in several Mediterranean populations. The population data deviate from the Hardy-Weinberg equilibrium in all populations for GpIIIa (CT)n polymorphism.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Africa, Northern
  • Alleles
  • Chi-Square Distribution
  • Data Interpretation, Statistical
  • France
  • Gene Frequency
  • Genetics, Population*
  • Humans
  • Integrin beta3 / genetics*
  • Italy
  • Mediterranean Region
  • Microsatellite Repeats*
  • Nitric Oxide Synthase Type II / genetics*
  • Plasminogen Activator Inhibitor 1 / genetics*
  • Polymerase Chain Reaction
  • Polymorphism, Genetic*
  • Sicily
  • Spain
  • Tissue Plasminogen Activator / genetics*
  • White People / genetics*

Substances

  • Integrin beta3
  • Plasminogen Activator Inhibitor 1
  • NOS2 protein, human
  • Nitric Oxide Synthase Type II
  • Tissue Plasminogen Activator