Solid phase synthesis of a prototype of a new class of biomimetic receptors for anionic carbohydrates

Org Biomol Chem. 2007 Mar 7;5(5):787-91. doi: 10.1039/b613660e. Epub 2007 Jan 26.

Abstract

A solid phase synthesis for a new biomimetic receptor was developed. First binding studies show that binds anionic carbohydrates such as glucose-1-phosphate and cAMP with association constants in the lower millimolar range in 20% buffered water in DMSO using both polar and apolar interactions.

MeSH terms

  • Anions / chemistry
  • Arginine / analogs & derivatives
  • Arginine / chemical synthesis
  • Arginine / chemistry
  • Biomimetic Materials / chemical synthesis*
  • Biomimetic Materials / chemistry
  • Carbohydrates / chemistry*
  • Combinatorial Chemistry Techniques
  • Molecular Mimicry
  • Molecular Structure
  • Protein Binding

Substances

  • Anions
  • Carbohydrates
  • Arginine