WNK4, as thiazides, shuts off NaCl reabsorption to stimulate Na/K exchange

Nephrol Dial Transplant. 2007 May;22(5):1305-8. doi: 10.1093/ndt/gfm010. Epub 2007 Feb 17.

Author

Francois Verrey¹

Affiliation

¹ Institute of Physiology, University of Zürich, Winterthurerstrasse 190, CH-8057 Zürich, Switzerland. verrey@access.unizh.ch

PMID: 17308320
DOI: 10.1093/ndt/gfm010

No abstract available

Publication types

Review

MeSH terms

Absorption / drug effects
Absorption / physiology
Animals
Blood Pressure / physiology
Diuretics
Humans
Hyperkalemia / physiopathology
Hypertension / physiopathology
Kidney Tubules, Distal / metabolism*
Mice
Mice, Transgenic
Mutation / genetics
Protein Serine-Threonine Kinases / genetics
Protein Serine-Threonine Kinases / physiology*
Sodium Chloride / metabolism*
Sodium Chloride Symporters / physiology
Sodium-Potassium-Exchanging ATPase / physiology*

Substances

Diuretics
Sodium Chloride Symporters
Sodium Chloride
Prkwnk4 protein, mouse
Protein Serine-Threonine Kinases
WNK4 protein, human
Sodium-Potassium-Exchanging ATPase