Transient neonatal hypothyroidism is associated with elevated serum anti-thyroglobulin antibody levels in newborns and their mothers

J Pediatr. 2007 Mar;150(3):315-7, 317.e2. doi: 10.1016/j.jpeds.2006.11.034.

Abstract

Transient congenital hypothyroidism (TCH) was detected in 6 of 35,067 newborns (1:5845 births) screened in Iran. Antithyroglobulin antibodies positivity was present in 4 of 6 (66.7%) of those with TCH and in 6 of 106 (5.7%) of those with "transient hyperthyrotropinemia and normal" diagnoses (P = .0005), but positivity was similar in newborns with transient hyperthyrotropinemia versus normal neonates (P = .397).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Autoantibodies / blood*
  • Cohort Studies
  • Congenital Hypothyroidism / diagnosis*
  • Congenital Hypothyroidism / epidemiology*
  • Female
  • Follow-Up Studies
  • Humans
  • Incidence
  • Infant, Newborn
  • Male
  • Neonatal Screening
  • Pregnancy
  • Pregnancy Complications / diagnosis
  • Pregnancy Complications / immunology*
  • Probability
  • Receptors, Thyrotropin / blood
  • Risk Assessment
  • Statistics, Nonparametric
  • Thyroid Function Tests

Substances

  • Autoantibodies
  • Receptors, Thyrotropin
  • anti-thyroglobulin