The synchronization properties of a network of inhibitory interneurons depend on the biophysical model

Biosystems. 2007 Apr;88(3):216-27. doi: 10.1016/j.biosystems.2006.08.011. Epub 2006 Nov 9.

Abstract

The synchronization properties of a pair of coupled fast spiking interneurons are studied by using the theory of weakly coupled oscillators. Four different biophysical models of the single fast spiking interneuron are used and the corresponding results are compared. It is shown that for a pair of identical coupled cells, the synchronization properties are model-dependent. In particular, the firing coherence of the network is strongly affected by the reversal potential, the kinetics of the inhibitory postsynaptic current and the electrical coupling; the activation properties of the sodium and potassium currents play a significant role too.

MeSH terms

  • Action Potentials
  • Animals
  • Biophysical Phenomena
  • Biophysics
  • Interneurons / physiology*
  • Kinetics
  • Mathematics
  • Models, Neurological*
  • Nerve Net / physiology*
  • Synapses / physiology
  • Systems Biology