Impact of organic material with different molecular weight( MW) on the adsorption performance of endocrine disrupting chemicals(EDCs)--bisphenol A (BPA) in water on granular activated carbon (GAC) were investigated. Compared to the adsorption capacity in deionized water, the qm values of Langmuir of BPA-raw water, BPA-filtered water and BPA-effluents after ozonation solution decrease 29.95 % ,43.56% and 44.44% respectively, and the k2 values of pseudo second order decrease 43.05 %, 49.75% and 56.38% respectively. On the hand, the secondary micropores may be blocked up by the organic matter with MW higher than 3 000, especially higher than 10 000, on the other hand, the direct sites competitive adsorption may be exists between the BPA molecule and the organic matter with MW lower than 3000, especially lower than 1000. Both of process may be resulted in reduction of the adsorption capacity, k2 value of adsorption kinetics of BPA onto GAC.