Sinugrandisterols A-D, trihydroxysteroids from the soft coral Sinularia grandilobata

Steroids. 2007 Apr;72(4):368-74. doi: 10.1016/j.steroids.2007.01.001. Epub 2007 Jan 16.

Abstract

Four new trihydroxysteroids, sinugrandisterols A-D (1-4), have been isolated from the CH(2)Cl(2)-soluble fraction of the EtOH extract of Sinularia grandilobata. The structures of these metabolites were determined on the basis of spectroscopic (IR, MS, and 1D and 2D NMR) analysis. The cytotoxicity of 1-4 toward a limited panel of cancer cell lines is also reported.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthozoa / chemistry*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cholestadienols / chemistry
  • Cholestadienols / isolation & purification
  • Cholestadienols / pharmacology
  • Drug Screening Assays, Antitumor
  • Humans
  • Hydroxycholesterols / chemistry
  • Hydroxycholesterols / isolation & purification
  • Hydroxycholesterols / pharmacology
  • Hydroxysteroids / chemistry*
  • Hydroxysteroids / isolation & purification
  • Hydroxysteroids / pharmacology*
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Spectrophotometry, Infrared
  • Tumor Cells, Cultured

Substances

  • 24-methylenecholest-5-en-1,3,7-triol
  • 5,6-epoxy-24-methylenecholesta-1,3,7-triol
  • 5,6-epoxy-24-methylenecholesta-5,22-dien-1,3,7-triol
  • Antineoplastic Agents
  • Cholestadienols
  • Hydroxycholesterols
  • Hydroxysteroids