Abstract
Substituted oxathiolone fused chalcones were prepared by condensation of 4-acetyl-5-methoxy-2-oxo-benz[1,3]oxathiole with benzaldehydes under acidic conditions. The compounds were tested for cytotoxic, antibacterial, antifungal and tuberculostatic activity. Three derivatives demonstrated weak activity against HeLa cells, two were slightly active against Micrococcus luteus and Staphylococcus aureus, and one was active against Mycobacterium tuberculosis H(37)Rv.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acids / chemistry*
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Anti-Bacterial Agents / chemical synthesis*
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Anti-Bacterial Agents / pharmacology*
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Antineoplastic Agents / chemical synthesis*
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Antineoplastic Agents / pharmacology*
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Catalysis
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Chalcones / chemical synthesis*
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Chalcones / pharmacology*
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Drug Screening Assays, Antitumor
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HeLa Cells
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Humans
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Microbial Sensitivity Tests
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Thiones / chemistry*
Substances
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Acids
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Anti-Bacterial Agents
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Antineoplastic Agents
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Chalcones
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Thiones