Abstract
[reaction: see text] A new class of thiourea catalysts have been developed which integrate saccharide and primary amine moieties into one small organic molecule. These simple catalysts are shown to be highly enantioselective for direct Michael addition of aromatic ketones to a range of nitroolefins (up to 98% ee).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetophenones / chemistry
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Alkenes / chemistry*
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Amines / chemistry*
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Carbohydrates / chemistry*
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Catalysis
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Ketones / chemistry*
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Molecular Structure
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Nitrogen / chemistry*
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Stereoisomerism
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Thiourea / chemical synthesis
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Thiourea / chemistry*
Substances
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Acetophenones
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Alkenes
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Amines
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Carbohydrates
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Ketones
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Thiourea
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Nitrogen
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acetophenone