Twelve cases died during the process of venous infusion were collected from 208 autopsy cases during the period of 2002-2004 in our center. The rate was 5.8% (12/208). In these 12 cases, 8 occurred in countryside clinic with poor medical condition. Negligence to take care of the indications and contraindications of venous infusion was the main cause of these accidents. Autopsy data showed that the cause of sudden death of 9 cases were related to the venous infusion directly or indirectly. The other 3 cases were died from original diseases of these patients and the time of these deaths was time of coincidence occasionally with the time of venous infusion.