Magnetic-fluorescent nanocomposites for biomedical multitasking

Chem Commun (Camb). 2006 Nov 21:(43):4474-6. doi: 10.1039/b610746j.

Abstract

Fluorescent magnetite nanocomposites based on magnetic nanoparticles, a polyhedral octaaminopropylsilsesquioxane and a porphyrin derivative have been prepared. The intracellular uptake of the nanocomposites by macrophage and bone osteoblast cells, and their potential as MRI contrast agents, has been demonstrated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Contrast Media / chemical synthesis*
  • Contrast Media / pharmacokinetics
  • Ferrosoferric Oxide
  • Fluorescence
  • Humans
  • Macrophages / metabolism
  • Magnetic Resonance Imaging
  • Magnetics
  • Nanocomposites / chemistry*
  • Nanoparticles
  • Osteoblasts / metabolism

Substances

  • Contrast Media
  • Ferrosoferric Oxide