Simulating leukocyte-venule interactions--a novel agent-oriented approach

J Tang; C A Hunt; J Mellein; K Ley

doi:10.1109/IEMBS.2004.1404376

Simulating leukocyte-venule interactions--a novel agent-oriented approach

Conf Proc IEEE Eng Med Biol Soc. 2004:2004:4978-81. doi: 10.1109/IEMBS.2004.1404376.

Authors

J Tang¹, C A Hunt, J Mellein, K Ley

Affiliation

¹ California University, San Francisco, CA, USA.

PMID: 17271432
DOI: 10.1109/IEMBS.2004.1404376

Abstract

Leukocyte recruitment into sites of inflammation involves a complex cascade of molecular interactions between the leukocyte and the endothelial cells of the inflamed venule. This report proposes a novel agent-oriented approach for simulating leukocyte-venule interactions during inflammation. We focus on modeling and simulating the initial steps of rolling, activation, and firm adhesion of neutrophils on TNF-alpha-treated mouse cremaster muscle venules.