Abstract
The methanolic extract from the male flowers of Borassus flabellifer was found to inhibit the increase of serum glucose levels in sucrose-loaded rats at a dose of 250 mg/kg, p.o. From the methanolic extract, six new spirostane-type steroid saponins, borassosides A-F (1-6), were isolated together with 23 known constituents. The structures of borassosides (1-6) were elucidated on the basis of chemical and physicochemical evidences. In addition, the principal steroid saponin, dioscin (13), inhibited the increase of serum glucose levels in sucrose-loaded rats at a dose of 50 mg/kg, p.o.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arecaceae / chemistry*
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Blood Glucose / metabolism
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Diosgenin / analogs & derivatives
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Diosgenin / chemistry
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Diosgenin / isolation & purification
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Diosgenin / pharmacology
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Dose-Response Relationship, Drug
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Hypoglycemic Agents / pharmacology*
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Male
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Methanol / chemistry
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Molecular Structure
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Plant Extracts / chemistry*
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Plants, Medicinal / chemistry*
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Rats
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Rats, Wistar
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Saponins / chemistry
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Saponins / isolation & purification*
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Saponins / pharmacology
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Time Factors
Substances
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Blood Glucose
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Hypoglycemic Agents
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Plant Extracts
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Saponins
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dioscin
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Diosgenin
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Methanol