Abstract
We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Abietanes / isolation & purification
-
Abietanes / pharmacology*
-
Aminoglycosides / pharmacology*
-
Anti-Bacterial Agents / isolation & purification
-
Anti-Bacterial Agents / pharmacology*
-
Drug Synergism
-
Enterococcus faecalis / drug effects
-
Enterococcus faecalis / growth & development
-
Enterococcus faecium / drug effects
-
Enterococcus faecium / growth & development
-
Methicillin Resistance
-
Microbial Sensitivity Tests
-
Phenanthrenes / isolation & purification
-
Phenanthrenes / pharmacology*
-
Plant Extracts / pharmacology*
-
Plant Leaves / chemistry
-
Pseudomonas aeruginosa / drug effects
-
Pseudomonas aeruginosa / growth & development
-
Salvia officinalis / chemistry
-
Serratia marcescens / drug effects
-
Serratia marcescens / growth & development
-
Staphylococcus aureus / drug effects
-
Staphylococcus aureus / growth & development
-
Vancomycin Resistance
Substances
-
Abietanes
-
Aminoglycosides
-
Anti-Bacterial Agents
-
Phenanthrenes
-
Plant Extracts
-
carnosol
-
salvin