Oxaliplatin-induced hemolytic anemia during adjuvant treatment of a patient with colon cancer: a case report

Anticancer Drugs. 2007 Mar;18(3):297-300. doi: 10.1097/CAD.0b013e3280102f4b.

Abstract

We report the case of a 64-year-old patient who developed autoimmune hemolytic anemia with thrombocytopenia and acute renal failure shortly after the infusion of the 11th cycle of adjuvant chemotherapy with oxaliplatin, folinic acid and 5-fluorouracil (FOLFOX 4), and was successfully treated by means of plasmapheresis, corticosteroids and dialysis. To the best of our knowledge, only seven other cases have been described in the literature, but we believe this serious adverse event induced by oxaliplatin is more frequent than this would suggest.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / chemically induced
  • Acute Kidney Injury / complications
  • Adrenal Cortex Hormones / therapeutic use
  • Anemia, Hemolytic, Autoimmune / chemically induced*
  • Anemia, Hemolytic, Autoimmune / drug therapy
  • Anemia, Hemolytic, Autoimmune / therapy*
  • Antineoplastic Agents / adverse effects*
  • Antineoplastic Agents / therapeutic use
  • Blood Cell Count
  • Chemotherapy, Adjuvant
  • Colonic Neoplasms / complications*
  • Colonic Neoplasms / drug therapy
  • Humans
  • Male
  • Middle Aged
  • Organoplatinum Compounds / adverse effects*
  • Organoplatinum Compounds / therapeutic use
  • Oxaliplatin
  • Plasmapheresis
  • Renal Dialysis

Substances

  • Adrenal Cortex Hormones
  • Antineoplastic Agents
  • Organoplatinum Compounds
  • Oxaliplatin