Abstract
A fast-moving gamma chain variant was discovered in the cord blood of a newborn during a screening program carried out in the northern region of Calabria, Southern Italy. The structural analysis showed a Gly----Glu substitution at position 25 of the G gamma chain indicating a new fetal hemoglobin variant that was named Hb F-Cosenza.
MeSH terms
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Amino Acid Sequence
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Blood Protein Electrophoresis
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Chromatography, High Pressure Liquid
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Electrophoresis, Cellulose Acetate
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Fetal Blood / chemistry
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Fetal Hemoglobin / genetics
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Fetal Hemoglobin / isolation & purification*
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Globins / genetics*
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Hemoglobins, Abnormal / genetics
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Hemoglobins, Abnormal / isolation & purification*
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Humans
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Infant, Newborn / blood
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Male
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Mass Screening
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Molecular Sequence Data
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Peptide Mapping
Substances
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Hemoglobins, Abnormal
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hemoglobin F-Cosenza
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Globins
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Fetal Hemoglobin