Abstract
Three polyketides containing a pyrone ring, neofusapyrone, fusapyrone, and deoxyfusapyrone, were isolated from the marine-derived fungus Fusarium sp. FH-146. Their structures were determined by extensive ID- and 2D-NMR and MS spectral analyses. Fusapyrone and deoxyfusapyrone were originally reported as a-pyrone derivatives; however, the revised structures indicate that they are gamma-pyrone derivatives. These three compounds exhibited antimicrobial activities.
MeSH terms
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Anti-Infective Agents / chemistry
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Aspergillus / drug effects
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Candida albicans / drug effects
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Fermentation
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Fusarium / chemistry*
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Fusarium / metabolism
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Microbial Sensitivity Tests
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Nuclear Magnetic Resonance, Biomolecular
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Optical Rotation
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Pseudomonas aeruginosa / drug effects
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Pyrones / chemistry*
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Pyrones / isolation & purification
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Pyrones / pharmacology
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Spectrometry, Mass, Fast Atom Bombardment
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Spectrophotometry, Infrared
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Spectrophotometry, Ultraviolet
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Staphylococcus aureus / drug effects
Substances
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Anti-Infective Agents
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Pyrones
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fusapyrone