PAK-in' up cGMP for the move

Jeffrey Settleman

doi:10.1016/j.cell.2007.01.002

PAK-in' up cGMP for the move

Cell. 2007 Jan 26;128(2):237-8. doi: 10.1016/j.cell.2007.01.002.

Author

Jeffrey Settleman¹

Affiliation

¹ MGH Cancer Center and Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA. settleman@helix.mgh.harvard.edu

PMID: 17254961
DOI: 10.1016/j.cell.2007.01.002

Abstract

Although guanylyl cyclases have been implicated in cell migration, how they are activated to promote cell motility is unknown. In this issue, report direct communication between guanylyl cyclases and the Rac-p21-activated kinase (PAK) signaling pathway--which is essential for cell migration--to promote cell motility, through allosteric activation of guanylyl cyclases by autophosphorylated PAK.

Publication types

Review
Comment

MeSH terms

Allosteric Regulation / physiology
Animals
Cell Membrane / metabolism
Cell Movement / physiology*
Cyclic GMP / biosynthesis*
Guanylate Cyclase / metabolism*
Humans
Phosphorylation
Protein Serine-Threonine Kinases / metabolism*
Signal Transduction / physiology*
p21-Activated Kinases
rac1 GTP-Binding Protein / metabolism

Substances

PAK1 protein, human
Protein Serine-Threonine Kinases
p21-Activated Kinases
rac1 GTP-Binding Protein
Guanylate Cyclase
Cyclic GMP