Adequately preparing for and responding to terrestrial (land-based) chemical spills are critical to the protection of human health and the environment. To facilitate analysis and support decision-making for such events, the authors have developed an environmental risk management system that characterizes the ability of a spilled chemical to immediately impact human health, groundwater, surface water, and soil resources, and incorporates these four risk areas into an overall measure of terrestrial chemical risk. This system incorporates a risk index model, leverages geographic information systems (GIS) technology, and contains a comprehensive chemical and environmental database to assess and delineate the immediate threat posed by a terrestrial chemical spill. It is designed to serve a variety of stakeholders, including managers and policy-makers, who would benefit from generating screening-level environmental risk assessments without requiring a technical background or collection of detailed environmental and chemical data. Areas of potential application include transportation routing, industrial zoning, environmental regulatory compliance and enforcement, spill response, and security planning.