Abstract
[structure: see text] Two new diterpenes, lagaspholones A (1) and B (2), have been isolated from the methanolic extract of Euphorbia lagascae, along with the known compounds (+)-dehydrovomifoliol, scopoletin, dehydrodiconiferyl diacetate, 3-indolcarbaldehyde, and 4-hydroxy-3,5-dimethoxybenzaldehyde. Their structures were elucidated by spectroscopic methods. Compounds 1 and 2 contain the rare jatropholane-type skeleton, characterized by a 5:6:7:3 fused ring system. A possible biosynthetic pathway for lagaspholones is proposed.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acetates / chemistry
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Acetates / isolation & purification
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Acetates / pharmacology
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Aldehydes / chemistry
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Aldehydes / isolation & purification
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Aldehydes / pharmacology
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Antineoplastic Agents, Phytogenic / chemistry*
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Antineoplastic Agents, Phytogenic / isolation & purification
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Antineoplastic Agents, Phytogenic / pharmacology
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Benzaldehydes / chemistry
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Benzaldehydes / isolation & purification
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Benzaldehydes / pharmacology
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Diterpenes / chemistry*
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Diterpenes / isolation & purification
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Diterpenes / pharmacology
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Euphorbia / chemistry*
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Molecular Structure
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Norisoprenoids / chemistry
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Norisoprenoids / isolation & purification
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Norisoprenoids / pharmacology
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Plant Extracts / chemistry*
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Plants, Medicinal*
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Scopoletin / chemistry
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Scopoletin / isolation & purification
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Scopoletin / pharmacology
Substances
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4-hydroxy-3,5-dimethoxybenzaldehyde
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Acetates
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Aldehydes
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Antineoplastic Agents, Phytogenic
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Benzaldehydes
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Diterpenes
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Norisoprenoids
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Plant Extracts
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lagaspholone A
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lagaspholone B
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jatrophone
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Scopoletin