Fabrication of hydroxyapatite-poly(epsilon-caprolactone) scaffolds by a combination of the extrusion and bi-axial lamination processes

J Mater Sci Mater Med. 2007 Jun;18(6):1017-23. doi: 10.1007/s10856-007-0155-9. Epub 2007 Jan 23.

Abstract

Hydroxyapatite (HA)/poly(epsilon-caprolactone) (PCL) composite scaffolds were fabricated using a combination of the extrusion and bi-axial lamination processes. Firstly, HA/PCL composites with various HA contents (0, 50, 60, 70 wt%) were prepared by mixing the HA powders and the molten PCL at 100 degrees C and then extruded through an orifice with dimensions of 600 x 600 microm to produce HA/PCL composite fibers. Isobutyl methacrylate (IBMA) polymer fiber was also prepared in a similar manner for use as a fugitive material. The 3-D scaffold was then produced by the bi-axial lamination of the HA/PCL and IBMA fibers, followed by solvent leaching to remove the IBMA. It was observed that the HA/PCL composites had a superior elastic modulus and biological properties, as compared to the pure PCL. The fabricated HA/PCL scaffold showed a controlled pore structure (porosity of approximately 49% and pore size of approximately 512 microm) and excellent welding between the HA/PCL fibers, as well as a high compressive strength of approximately 7.8 MPa.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry
  • Cell Line, Tumor
  • Cell Proliferation
  • Durapatite / chemistry*
  • Humans
  • Materials Testing
  • Osteosarcoma / ultrastructure
  • Polyesters / chemistry*
  • Tissue Engineering / methods

Substances

  • Biocompatible Materials
  • Polyesters
  • polycaprolactone
  • Durapatite