Micafungin activity against Candida bloodstream isolates: effect of growth medium and susceptibility testing method

Diagn Microbiol Infect Dis. 2007 May;58(1):129-32. doi: 10.1016/j.diagmicrobio.2006.10.017. Epub 2007 Jan 19.

Abstract

An excellent correlation between micafungin MICs were demonstrated against Candida bloodstream isolates (n = 200) by the Sensititre YeastOne and National Committee for Clinical Laboratory Standards M27-A2 methods. Use of antibiotic medium 3 (2%) dextrose improved micafungin activity and was not associated with paradoxical growth as noted with 3 Candida isolates tested using RPMI (2%) dextrose.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Blood / microbiology*
  • Candida / drug effects*
  • Candida / growth & development
  • Candida / isolation & purification
  • Candidiasis / microbiology
  • Culture Media / chemistry*
  • Echinocandins
  • Fungemia / microbiology*
  • Glucose
  • Humans
  • Lipopeptides
  • Lipoproteins / pharmacology*
  • Micafungin
  • Microbial Sensitivity Tests / methods
  • Microbial Sensitivity Tests / standards
  • Peptides, Cyclic / pharmacology*

Substances

  • Antifungal Agents
  • Culture Media
  • Echinocandins
  • Lipopeptides
  • Lipoproteins
  • Peptides, Cyclic
  • Glucose
  • Micafungin