Deciphering the underlying genetic and epigenetic events leading to gastric carcinogenesis

J Cell Physiol. 2007 May;211(2):287-95. doi: 10.1002/jcp.20982.

Abstract

Gastric cancer is a common aggressive malignancy. Although its incidence shows considerable variation among different countries, gastric cancer is still a major health problem worldwide. The causes of stomach cancer are not completely understood. What is clear is that gastric cancer is a multi-stage process involving genetic and epigenetic factors. This review is an in-depth study of the known genetic and epigenetic processes in the development of this tumor, and delineates possible approaches in gene and epigenetic therapy.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use
  • Cell Transformation, Neoplastic / genetics*
  • DNA Methylation / drug effects
  • DNA Modification Methylases / antagonists & inhibitors
  • Disease Progression
  • Enzyme Inhibitors / pharmacology
  • Enzyme Inhibitors / therapeutic use
  • Epigenesis, Genetic*
  • Gene Expression Regulation, Neoplastic* / drug effects
  • Genetic Therapy / methods
  • Histone Deacetylase Inhibitors
  • Humans
  • Stomach Neoplasms / drug therapy
  • Stomach Neoplasms / genetics*
  • Stomach Neoplasms / therapy

Substances

  • Antineoplastic Agents
  • Enzyme Inhibitors
  • Histone Deacetylase Inhibitors
  • DNA Modification Methylases