We report the case of a 60-year-old woman with Parkinson's disease and severe motor fluctuations. During OFF periods she presented both motor and non-motor symptoms, which ameliorated rapidly after each levodopa dose. After undergoing bilateral STN DBS, motor complications improved markedly while non-motor symptoms remained unchanged. Levodopa response is regarded as a good predictive factor for the prognosis of motor symptoms in PD patients undergoing surgery. However, our case suggests that its relation with the prognosis of non-motor symptoms might be different and remains to be addressed.