[Construction recombinant adenovirus vector expressing murine endostatin and inhibition of blood endothelial cells growth]

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2006 Dec;23(6):1294-7.
[Article in Chinese]

Abstract

We constructed recombinant adenovirus vector expressing murine endostatin and evaluated the Inhibition of human umbilical vein endothelial cells (HUVEC). We proved that endostatin significantly suppressed the S phase fraction, inhibited proliferation and increased the apoptotic index of HUVEC.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenoviridae / genetics*
  • Adenoviridae / metabolism
  • Animals
  • Apoptosis / drug effects*
  • Cell Proliferation / drug effects
  • Cells, Cultured
  • Endostatins / biosynthesis*
  • Endostatins / genetics
  • Endothelial Cells / cytology*
  • Genetic Vectors / genetics
  • Humans
  • Mice
  • Recombinant Proteins / biosynthesis*
  • Recombinant Proteins / genetics
  • Recombinant Proteins / pharmacology
  • Umbilical Veins / cytology

Substances

  • Endostatins
  • Recombinant Proteins