Prospects for the use of synthetic antigens in immunodiagnosis

Biomed Sci. 1990;1(6):553-64.

Abstract

Methods for the localization and prediction of protein antigenic determinants are described, and the diagnostic potential of synthetic peptide antigens in cases of HIV, hepatitis B, and influenza is demonstrated. Attention is concentrated on the principles governing the creation and application of artificial diagnostic preparations.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Enzyme-Linked Immunosorbent Assay
  • Epitopes / immunology
  • HIV Envelope Protein gp120 / genetics
  • HIV Envelope Protein gp120 / immunology
  • HIV Envelope Protein gp41 / genetics
  • HIV Envelope Protein gp41 / immunology
  • HIV Infections / diagnosis*
  • HIV Infections / immunology
  • Hemagglutinins / immunology
  • Hepatitis B / diagnosis*
  • Hepatitis B / immunology
  • Hepatitis B Antigens / immunology
  • Humans
  • Influenza, Human / diagnosis*
  • Influenza, Human / immunology
  • Molecular Sequence Data
  • Vaccines, Synthetic*

Substances

  • Epitopes
  • HIV Envelope Protein gp120
  • HIV Envelope Protein gp41
  • Hemagglutinins
  • Hepatitis B Antigens
  • Vaccines, Synthetic