Orbital and muscle involvement in multiple myeloma

Can J Ophthalmol. 2006 Dec;41(6):733-6. doi: 10.3129/i06-067.

Abstract

Case report: We report 2 cases of orbital plasmacytoma in patients with known multiple myeloma. Orbital spread with secondary maxillary sinus involvement is reported in the first case. Case 2 is the first report of immunoglobulin A kappa light chain multiple myeloma involving orbital recti muscles. Computed axial tomography and magnetic resonance imaging aided the diagnosis, confirmed with histopathologic studies.

Comments: Extraskeletal spread is rare and orbital involvement is exceedingly uncommon. From a review of the literature since 1972, we conclude that the immunoglobulin G type of multiple myeloma, whether lambda or kappa light chain, may be a risk factor for orbital involvement.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Biopsy
  • Diagnosis, Differential
  • Fatal Outcome
  • Female
  • Humans
  • Immunoglobulin A / metabolism
  • Immunoglobulin kappa-Chains / metabolism
  • Immunohistochemistry
  • Magnetic Resonance Imaging
  • Middle Aged
  • Multiple Myeloma / diagnosis*
  • Multiple Myeloma / metabolism
  • Oculomotor Muscles / diagnostic imaging*
  • Oculomotor Muscles / pathology*
  • Orbital Neoplasms / diagnosis*
  • Orbital Neoplasms / metabolism
  • Risk Factors
  • Tomography, X-Ray Computed

Substances

  • Immunoglobulin A
  • Immunoglobulin kappa-Chains