Fluorescent CXCR4 chemokine receptor antagonists: metal activated binding

Chem Commun (Camb). 2007 Jan 28:(4):416-8. doi: 10.1039/b614557d. Epub 2006 Dec 4.

Abstract

The copper(II) complex of a novel rhodamine-azamacrocycle conjugate binds to the CXCR4 chemokine receptor and competes effectively against anti-CXCR4 monoclonal antibodies. The copper macrocycle unit adopts a trans-II configuration in the solid state.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Crystallography, X-Ray
  • Flow Cytometry
  • Humans
  • Jurkat Cells
  • Metals / pharmacology*
  • Microscopy, Fluorescence / methods*
  • Models, Molecular
  • Molecular Structure
  • Protein Binding / drug effects
  • Receptors, CXCR4 / antagonists & inhibitors*
  • Receptors, CXCR4 / chemistry
  • Receptors, CXCR4 / metabolism*

Substances

  • Metals
  • Receptors, CXCR4