Passiflora alata and Passiflora edulis spray-dried aqueous extracts inhibit inflammation in mouse model of pleurisy

Fitoterapia. 2007 Feb;78(2):112-9. doi: 10.1016/j.fitote.2006.09.030. Epub 2006 Nov 14.

Abstract

The aqueous leaves extracts of Passiflora alata (100-300 mg/kg, i.p.) and Passiflora edulis (100-1000 mg/kg, i.p.) possess a significant antiinflammatory activity on carrageenan-induced pleurisy in mice. Treatment with the extracts inhibited leukocyte migration and reduced the formation of exudate. Moreover, a significant inhibition of myeloperoxidase and adenosine-deaminase activities was observed at the doses tested (100 or 250 mg/kg, i.p.). At the same doses, a significant decrease of serum C-reactive protein was observed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Inflammatory Agents, Non-Steroidal / administration & dosage
  • Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • C-Reactive Protein / drug effects
  • Carrageenan
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Female
  • Male
  • Mice
  • Passiflora*
  • Phytotherapy*
  • Plant Extracts / administration & dosage
  • Plant Extracts / pharmacology*
  • Plant Extracts / therapeutic use
  • Plant Leaves
  • Pleurisy / blood
  • Pleurisy / chemically induced
  • Pleurisy / drug therapy*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Plant Extracts
  • Carrageenan
  • C-Reactive Protein