Objective: To establish and evaluate the Caco-2 cell model.
Methods: Caco-2 cell model was evaluated by morphology feature, TEER alkaline phosphatase and the transport of Propranolol.
Results: The determined values were corresponding to the references. The integrality, permeability and the expression of alkaline phosphatase in the cell model were superior.
Conclusion: The established Caco-2 cell model can be used to study the absorption mechanism of oral administration drug.