Necrotizing crescentic glomerulonephritis--a conditional knockout model discloses new therapeutic challenges

Nephrol Dial Transplant. 2007 Apr;22(4):1020-2. doi: 10.1093/ndt/gfl776. Epub 2007 Jan 8.

Author

Maria Pia Rastaldi¹

Affiliation

¹ Renal Immunopathology Laboratory, Fondazione D'Amico per la Ricerca sulle Malattie Renali, c/o San Carlo Hospital, via Pio II, 3 20153 Milan, Italy. mp.rastaldi@fastwebnet.it

PMID: 17210602
DOI: 10.1093/ndt/gfl776

No abstract available

Publication types

Review

MeSH terms

Animals
Chemokine CXCL12
Chemokines, CXC / genetics
Chemokines, CXC / metabolism
Disease Models, Animal
Glomerulonephritis / genetics*
Glomerulonephritis / metabolism
Glomerulonephritis / pathology
Humans
Hypoxia-Inducible Factor 1, alpha Subunit / genetics
Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
Kidney Cortex Necrosis / genetics*
Kidney Cortex Necrosis / metabolism
Kidney Cortex Necrosis / pathology
Mice
Mice, Knockout
Podocytes / metabolism
Podocytes / pathology
Receptors, CXCR4 / genetics
Receptors, CXCR4 / metabolism
Von Hippel-Lindau Tumor Suppressor Protein / genetics
Von Hippel-Lindau Tumor Suppressor Protein / metabolism

Substances

CXCL12 protein, human
CXCR4 protein, mouse
Chemokine CXCL12
Chemokines, CXC
Cxcl12 protein, mouse
Hif1a protein, mouse
Hypoxia-Inducible Factor 1, alpha Subunit
Receptors, CXCR4
Von Hippel-Lindau Tumor Suppressor Protein
VHL protein, mouse