Adaptive response in irradiated human lymphocytes: radiobiological and genetical aspects

E K Khandogina; G R Mutovin; S V Zvereva; A V Antipov; D O Zverev; A P Akifyev

doi:10.1016/0027-5107(91)90073-w

Adaptive response in irradiated human lymphocytes: radiobiological and genetical aspects

Mutat Res. 1991 Dec;251(2):181-6. doi: 10.1016/0027-5107(91)90073-w.

Authors

E K Khandogina¹, G R Mutovin, S V Zvereva, A V Antipov, D O Zverev, A P Akifyev

Affiliation

¹ 2nd Moscow Medical Institute, Academy of Sciences of the U.S.S.R.

PMID: 1720868
DOI: 10.1016/0027-5107(91)90073-w

Abstract

The adaptive response (AR) in human lymphocytes in different experimental protocols was investigated. The AR was found to be present in cells pre-exposed to 3 cGy of X-rays in G0, G1 and S phase as well as with tritiated water (4 muCi/ml) when the 'challenge' dose was given in G2. There was no AR after prior exposure of the cells in S phase to secondary irradiation from 70 GeV protons. The AR was not observed after preliminary X-irradiation of the lymphocytes in G0 and G1 and 'challenge' irradiation in G1. Cells from 6 patients with Down's syndrome were tested. At least 5 of them did not show the AR. The AR is considered to be a phenomenon of the antimutagenic aftereffect.

MeSH terms

Adaptation, Physiological*
Adult
Cell Cycle
Cells, Cultured
Down Syndrome / blood
Female
Humans
Infant
Lymphocytes / metabolism
Lymphocytes / radiation effects*
Male
Radiation Tolerance