1-O-alkylglycerols reduce the stimulating effects of bFGF on endothelial cell proliferation in vitro

Frédérique Pédrono; Bernard Saïag; Jacques-Philippe Moulinoux; Alain B Legrand

doi:10.1016/j.canlet.2006.11.028

1-O-alkylglycerols reduce the stimulating effects of bFGF on endothelial cell proliferation in vitro

Cancer Lett. 2007 Jun 28;251(2):317-22. doi: 10.1016/j.canlet.2006.11.028. Epub 2007 Jan 4.

Authors

Frédérique Pédrono¹, Bernard Saïag, Jacques-Philippe Moulinoux, Alain B Legrand

Affiliation

¹ Laboratoire de Pharmacologie Moléculaire, Faculté de Pharmacie, Université de Rennes I, Rennes, France.

PMID: 17207571
DOI: 10.1016/j.canlet.2006.11.028

Abstract

1-O-alkylglycerols (alkyl-Gro) are natural etherlipids with multiple biological activities. We previously demonstrated that alkyl-Gro reduce endothelial permeability. Here we showed that alkyl-Gro reduced the basic Fibroblast Growth Factor (bFGF)-stimulated endothelial cell proliferation in a concentration-dependent manner. The effects of 0.5 and 5 ng/ml bFGF on growth were completely suppressed after 72 h-treatment by 50 microM alkyl-Gro. Since bFGF greatly increased (+56%+/-15) the production of 1-O-alkyl-2-acyl-sn-glycerophosphate in alkyl-Gro-treated endothelial cells, our data suggest that the observed effects of alkyl-Gro could be mediated through PLD activation. Inhibition of bFGF-stimulated endothelial proliferation could support anti-angiogenic activity of alkyl-Gro.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Angiogenesis Inhibitors
Animals
Cattle
Cell Proliferation / drug effects
Cells, Cultured
Endothelial Cells / drug effects*
Endothelium, Vascular
Fibroblast Growth Factor 2 / pharmacology*
Glycerol / analogs & derivatives*
Glycerol / pharmacology
Glyceryl Ethers / pharmacology*
Tumor Cells, Cultured

Substances

Angiogenesis Inhibitors
Glyceryl Ethers
Fibroblast Growth Factor 2
Glycerol