Abstract
Adoptive transfer of lymphoid cells from Copolymer 1 (Cop-1) immunized mice leads to T cell accumulation within the substantia nigra, modulation of microglial responses, upregulation of glial cell derived neurotrophic factor, and protection of the nigrostriatum following 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication. We now demonstrate that T cells isolated from lymph nodes and spleens of Cop-1 immunized animals protect the nigrostriatal system from MPTP-induced neurodegeneration in a dose-dependent manner. CD4+ T cells elicited the most significant neuroprotective response while high titers of anti-Cop-1 antibodies showed no effect. These data further support the use of immunomodulatory strategies for Parkinson's disease.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Adoptive Transfer / methods
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Animals
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Antineoplastic Combined Chemotherapy Protocols
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CD4-Positive T-Lymphocytes / physiology*
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Cisplatin
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Corpus Striatum / pathology
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Disease Models, Animal
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Dopamine / metabolism*
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Dose-Response Relationship, Drug
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Enzyme-Linked Immunosorbent Assay / methods
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Flow Cytometry / methods
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Glatiramer Acetate
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Ifosfamide
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Male
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Mice
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Mitomycin
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Neurons / physiology*
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Parkinson Disease, Secondary* / chemically induced
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Parkinson Disease, Secondary* / pathology
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Parkinson Disease, Secondary* / therapy
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Peptides / immunology
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Peptides / therapeutic use*
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Substantia Nigra / pathology
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Tyrosine 3-Monooxygenase / metabolism
Substances
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Peptides
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Mitomycin
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Glatiramer Acetate
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1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
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Tyrosine 3-Monooxygenase
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Cisplatin
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Ifosfamide
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Dopamine