In vitro activities of amphotericin B, caspofungin, itraconazole, posaconazole, and voriconazole against 45 clinical isolates of zygomycetes: comparison of CLSI M38-A, Sensititre YeastOne, and the Etest

Antimicrob Agents Chemother. 2007 Mar;51(3):1126-9. doi: 10.1128/AAC.01539-06. Epub 2006 Dec 28.

Abstract

We evaluated the activities of amphotericin B, itraconazole, voriconazole, caspofungin, and posaconazole against zygomycetes by CLSI M38-A, Etest and Sensititre. The most active drug was posaconazole, followed by amphotericin B and itraconazole. The correlation of the Etest and Sensititre with CLSI M38-A was moderate for posaconazole but poor for the others.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology*
  • Fungi / drug effects*
  • Humans
  • Microbial Sensitivity Tests / instrumentation*
  • Quality Control
  • Zygomycosis / microbiology*

Substances

  • Antifungal Agents