99mTc(CO)3-VIP analogues: preparation and evaluation as tumor imaging agent

Kanchan Kothari; Sudhanand Prasad; Aruna Korde; Archana Mukherjee; Archana Mathur; Manu Jaggi; Meera Venkatesh; Ambikalmajan M R Pillai; Rama Mukherjee; Natesan Ramamoorthy

doi:10.1016/j.apradiso.2006.11.001

99mTc(CO)3-VIP analogues: preparation and evaluation as tumor imaging agent

Appl Radiat Isot. 2007 Apr;65(4):382-6. doi: 10.1016/j.apradiso.2006.11.001. Epub 2006 Dec 27.

Authors

Kanchan Kothari¹, Sudhanand Prasad, Aruna Korde, Archana Mukherjee, Archana Mathur, Manu Jaggi, Meera Venkatesh, Ambikalmajan M R Pillai, Rama Mukherjee, Natesan Ramamoorthy

Affiliation

¹ Radiopharmaceuticals Division, Bhabha Atomic Research Centre, Mumbai 400085, India.

PMID: 17194598
DOI: 10.1016/j.apradiso.2006.11.001

Abstract

Vasoactive intestinal peptide (VIP) receptors are expressed abundantly on many types of tumors and, hence, radiolabeled VIP analogues are being explored for tumor imaging and therapy. Here, we report synthesis of three VIP analogues and their radiolabeling with (99m)Tc via a novel tricarbonyl synthon. The radiolabeled product could be prepared in high yields (>95%) and stability. In vitro studies showed significant uptake of (99m)Tc(CO)((3))-VP05 in human colon carcinoma cells. Biodistribution studies in animal tumor model showed 0.4-1%ID/g tumor uptake.

Publication types

Evaluation Study

MeSH terms

Amino Acid Sequence
Animals
Colonic Neoplasms / diagnostic imaging*
Humans
Isotope Labeling
Mice
Organotechnetium Compounds / chemical synthesis*
Organotechnetium Compounds / pharmacokinetics
Radionuclide Imaging
Vasoactive Intestinal Peptide / analogs & derivatives*
Vasoactive Intestinal Peptide / chemical synthesis
Vasoactive Intestinal Peptide / pharmacokinetics

Substances

Organotechnetium Compounds
techentium 99m tricarbonyl VD5 peptide
technetium 99m tricarbonyl VD4 peptide
technetium 99m tricarbonyl VP05 peptide
Vasoactive Intestinal Peptide