Abstract
Three new ent-kaurane diterpenoids, parvifoline Z (1), parvifoline AA (2), and parvifoline AB (3), together with 14 known compounds, were isolated from the leaves of Isodon parvifolius. The structures of the new compounds were elucidated by 1D- and 2D-NMR spectroscopy and mass spectrometry, and by comparison with known compounds. These three new diterpenoids included three types of ent-kauranoids, namely, C(20)-non-oxygenated-ent-kauranoid, 7,20-cyclo-ent-kauranoid and 6,7-seco-ent-kauranoid-7,20-olide. Compounds 1 and 2 exhibited significant cytotoxicities against A549, HT-29, and K562 cell lines.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents, Phytogenic* / chemistry
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Antineoplastic Agents, Phytogenic* / isolation & purification
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Antineoplastic Agents, Phytogenic* / pharmacology
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cell Survival / drug effects
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Diterpenes, Kaurane* / chemistry
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Diterpenes, Kaurane* / isolation & purification
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Diterpenes, Kaurane* / pharmacology
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Dose-Response Relationship, Drug
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Drug Screening Assays, Antitumor
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Humans
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Isodon / chemistry*
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Magnetic Resonance Spectroscopy
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Mass Spectrometry
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Molecular Structure
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Plant Extracts / chemistry
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Plant Extracts / isolation & purification
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Plant Extracts / pharmacology
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Plant Leaves / chemistry
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Plants, Medicinal*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents, Phytogenic
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Diterpenes, Kaurane
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Plant Extracts