Absolute configuration of sporotricale and structure of 6-hydroxysporotricale

J Nat Prod. 2006 Dec;69(12):1793-5. doi: 10.1021/np060212v.

Abstract

The absolute configuration of the two stereocenters of (+)-sporotricale (2a), a bioactive phthalide secondary metabolite, was determined through circular dichroism and by applying Mosher's method. The structure of 6-hydroxysporotricale (2c), isolated from cultures in vitro of Sporotrichum laxum, was also elucidated.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antineoplastic Agents / chemistry*
  • Antineoplastic Agents / isolation & purification
  • Antineoplastic Agents / pharmacology
  • Benzofurans / chemistry*
  • Benzofurans / isolation & purification
  • Benzofurans / pharmacology
  • Chickens
  • Chorioallantoic Membrane / drug effects
  • Drug Screening Assays, Antitumor
  • Endothelial Cells / drug effects
  • Fibroblast Growth Factors / drug effects
  • Molecular Structure
  • Neovascularization, Physiologic / drug effects
  • Sporothrix / chemistry*
  • Stereoisomerism
  • Zygote / drug effects

Substances

  • 6-hydroxysporotricale
  • Antineoplastic Agents
  • Benzofurans
  • sporotricale
  • Fibroblast Growth Factors